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Why is one twin smaller than the other? New study may hold answers


When a baby is born small, it’s often attributed to genetic factors or maternal risk factors like poor nutrition or smoking.

But a new study led by researchers at Boston Children’s Hospital now finds that slower transport of oxygen from mother to baby across the placenta predicts slower fetal growth, as well as a smaller brain and liver.

The study, published in Scientific Reports is the first to make a direct connection between birth outcomes and placental oxygen transport.

By studying identical twins, the researchers were uniquely able to control for both genetic factors and maternal risk factors. Although identical twins also share a placenta, it is divided into two separate compartments, and one may be healthier than the other.

In the new study, researchers followed seven sets of identical twins all the way to birth, specifically tracking pregnancies in which one twin was smaller than the other.

P. Ellen Grant, MD, director of Boston Children’s Fetal-Neonatal Neuroimaging and Developmental Science Center,  and Elfar Adalsteinsson, PhD at MIT have developed a noninvasive method that uses MRI to map the timing of oxygen delivery across the placenta in real time. Using this technique, called Blood-Oxygenation-Level-Dependent (BOLD) MRI, they showed that dysfunctional placentas have large regions with slow oxygen transport to the fetus.

At 29 to 34 weeks of pregnancy, the seven mothers underwent BOLD MRI for about 30 minutes. While they inhaled pure oxygen for 10-minute stretches, the research team measured how long it took oxygen to reach its maximum concentration in the placenta, known as the time to plateau (TTP), and then how long it took for the oxygen to pass through the umbilical cord into the fetus and penetrate the brain and liver.

The research team found that a longer TTP in the placenta correlated with lower liver and brain volumes and lower newborn birth weights. TTP also correlated with placental pathology when placentas were examined after birth by placental pathologist Drucilla Roberts, MD, at Massachusetts General Hospital (MGH).

Grant hopes her team’s work will be used to better understand pregnancy risk factors, develop a prenatal test for mothers in whom placental dysfunction is suspected and ultimately improve prenatal care.  “Our next goal is to figure out what causes variation in oxygen transport in the placenta and identify a cutoff value that would be of concern in a pregnancy, including singleton pregnancies,” she says. “Then, we can think about potential treatments to improve placental oxygen transport, and use our methods to immediately assess the success of these treatments.”

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